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Medicine Sick Day Guidance

Dehydration is due to a loss of fluid from your body. Vomiting, diarrhoea and fever (high temperature,
sweats, shaking) can make you dehydrated. If you are sick once or have diarrhoea once, then you
are unlikely to become dehydrated. Having two or more episodes of vomiting or diarrhoea or having
prolonged fever can lead to dehydration.

Taking certain medicines when you are dehydrated can result in you developing a more serious

Medicines that make dehydration more likely are:

Diuretics Sometimes called “water pills” e.g. Furosemide, Spironolactone, Bendroflumethiazide

Medicines that can stop your kidneys working if you are dehydrated are:

ACE inhibitors Medicine names ending in “pril” e.g. ramipril, perindopril, lisinopril
ARBs Medicine names ending in “sartan” e.g. losartan, candesartan, valsartan
NSAIDs Anti-inflammatory painkillers e.g. Ibuprofen, diclofenac, naproxen

Medicines that make you more likely to have a side effect called lactic acidosis if dehydrated:

Metformin A medicine for diabetes
SGLT2’s Medicines ending in “gliflozin” e.g. Canagliflozin, Dapagliflozin, Empagliflozin

“Medicine Sick Day Guidance”

If you develop a dehydrating illness, temporarily stop taking the medication listed in this leaflet. Restart
your medication once you have recovered. Take it as you would normally, you do not need to take any
extra tablets for the doses you have missed. If your symptoms persist for more than 48 hours contact
your GP, Pharmacist or Out of Hours GP service for advice.

Remember to keep drinking small amounts of fluid regularly on your sick days too. If you are only passing
small amounts of urine you may need admission to hospital and you should alert your GP to this. Please
do not delay calling your GP of the out of hours service if your urine output decreases to only small